CpG-island methylation study of liver fluke-related cholangiocarcinoma
نویسندگان
چکیده
منابع مشابه
Liver Fluke Induces Cholangiocarcinoma
Liver fl uke infection caused by Opisthorchis viverrini, O. felineus, and Clonorchis sinensis is a major public health problem in East Asia and Eastern Europe. Currently, more than 600 million people are at risk of infection with these trematodes [1]. O. viverrini is endemic in Southeast Asian countries, including Thailand, Lao People’s Democratic Republic, Vietnam, and Cambodia [2], and C. sin...
متن کاملCholangiocarcinoma Associated with Liver Fluke Infection in an Iranian Patient
Biliary liver flukes are common parasites in some regions of the world where consumption of raw fresh-water fish is a cultural practice. Clonorchis sinensis and Opisthorchis species are the major biliary liver flukes associated with human disease. Some of these parasites are highly associated with cholan...
متن کاملPredicting aberrant CpG island methylation.
Epigenetic silencing associated with aberrant methylation of promoter region CpG islands is one mechanism leading to loss of tumor suppressor function in human cancer. Profiling of CpG island methylation indicates that some genes are more frequently methylated than others, and that each tumor type is associated with a unique set of methylated genes. However, little is known about why certain ge...
متن کاملAccelerated age-related CpG island methylation in ulcerative colitis.
CpG island hypermethylation is a mechanism of gene silencing that can be usurped by neoplastic cells to inactivate undesirable genes. In the colon, hypermethylation often starts in normal mucosa as a function of age and is markedly increased in cancer. To test the hypothesis that subjects at increased risk of colon cancer have higher levels of methylation in their nonneoplastic mucosa, we studi...
متن کاملLiver kinase B1 promoter CpG island methylation is related to lung cancer and smoking.
The aim of this study was to explore the association of CpG islands methylation of liver kinase B1 (LKB1) with primary lung cancer and smoking, providing a theoretical basis for the demethylating drug to treat lung cancer by detecting the LKB1 promoter CpG methylation. mRNA expression of LKB1 were detected by in situ hybridization and methylation status on Hap II locus of the promoter of LKB1 w...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2011
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.2011.102